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5-MeO -DMT (5-methoxy-N,N-dimethyltryptamine) is a powerful and relatively obscure psychedelic and entheogen of the tryptamine class. It is found in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years.[1] In modern times, however, it is primarily acquired in its synthetic powder form through the use of online research chemical vendors.

When taken as a drug in its purified or synthetic form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO -DMT is active orally when taken with an MAOI, but according to numerous reports this combination often tends to be extremely unpleasant and has a strong body load.

5-MeO-DMT or 5-methoxy-N,N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO -DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO -MiPT, although it radically differs in its effects.


Tactile enhancement – This particular component is perhaps the most overwhelming sensation within the entirety of the 5-MeO-DMT experience. It increases the intensity of tactile sensations to such an overwhelming extent that it can induce a sensation of sustained and repeatable full body orgasm within every nerve ending across the entire body to a degree not found within any other psychedelic drug. The experience of this results in the perception of having a difficulty sustaining the act of breathing. It is worth noting, however, that this is not a genuine or dangerous experience of respiratory depression and is considered to be safe.

Bodily control enhancement
Bodily pressures
Changes in gravity
Motor control loss
Perception of increased weight
Pupil dilation
Skin flushing
Temperature regulation suppression
Cognitive effects

Analysis enhancement
Conceptual thinking
Subconscious communication
Emotion enhancement
Increased music appreciation
Memory suppression
Ego death
Thought connectivity
Time distortion
Unity and interconnectedness


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The most commonly reported route of administration is by vaporization of the freebase drug, which is generally not a pharmaceutically acceptable approach compared to other dosage forms.

While other intraperitoneal routes of administration with 5-MeO-DMT such as dry powder inhalation, transdermal, or intravenous administration are possible, an intramuscular injection has been identified as a preferable compromise for administering this material.

In addition to allowing precise metering of dose, the intramuscular injection of 5-MeO -DMT in a naturalistic setting has been previously reported and was claimed to possess an advantageous duration of action compared to the intense rapid-onset produced by other intraperitoneal routes. (19) The injectable drug formulated as a 20 mg/mL solution of API in sterile water with excipients is capable of delivering a precise dose of API in the range of 2–15 mg, consistent with the dose range described in previous anecdotal reports with this material.

5-MeO -DMT freebase has low water solubility (<10 mg/mL) and the unionized amine may degrade on exposure to atmospheric oxygen to give the corresponding N-oxide degradant (vide infra). A water-soluble, pharmaceutically acceptable salt form of 5-MeO -DMT was therefore required.

In parallel to the exploration of viable synthetic routes to 5-MeO-DMT freebase, a range of pharmaceutically acceptable salt forms were considered from acids with sufficient pKa difference to fully protonate 6, including the counterions chloride, sulfate, fumarate, succinate, maleate, lysate, oxalate, benzoate, tartrate, mesylate, or acetate.


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